No 09+10/2009 » Abstract

Relation Between 25(OH)-Vitamin D Deficiency and Markers of Bone Formation and Resorption in Haemodialysis Patients

by Neda LJ Milinkovic, Nada T Majkic-Singh, Dusko D Mirkovic, Andjelo D Beletic, Svetlana D Pejanovic, Svetlana T Vujanic

Deficient serum 25-hydroxyvitamin D [25(OH)D] may contribute to the impaired bone turnover of end stage renal disease patients. In 112 hemodialysed patients we analysed the relation between 25(OH)D and bone alkaline phosphatase (BALP), beta-CrossLaps (beta-CTx) and iPTH. We analysed parameters according to the manufacturers' instructions. We found potentially significant vitamin D deficiency: 71% of patients had 25(OH)D levels below 50 nmol/L. In patients with iPTH below 150 pg/mL (n = 57), we observed significantly low 25(OH) (p<0.01). In addition, patients with iPTH above 300 pg/mL had higher BALP levels (p<0.05). There were negative correlations between serum 25(OH)D and both BALP and iPTH (r = -0.225, p<0.05 and r = -0.331, p<0.05). Beta-CTx levels were significantly higher in patients who did not receive vitamin D supplementation (p<0.01). In addition, reduced BALP and iPTH levels indicate decreased bone turnover. Recorded data could signify that vitamin D deficiency may contribute to the impaired bone metabolism of hemodialysis patients.

Clin. Lab. 2009;55(9-10):333-339.

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