Clinical Laboratory

You have to be registered and logged in for purchasing articles.

Abstract	Investigation of Possible Interference by Digoxin-Like Immunoreactive Substances on the Architect® iDigoxin CMIA in Serum Samples from Pregnant Women, and Patients with Liver Disease, Renal Insufficiency, Critical Illness, and Kidney and Liver Transplant by Natalia Lampon, Fernando Pampin, J. Carlos Tutor

	Background: Although the possible interference of digoxin-like immunoreactive substances (DLIS) on the Architect ® iDigoxin chemiluminiscent microparticle immunoassay (CMIA) has been emphasized by the manufacturer, a specific study about this subject has still not been carried out. Methods: Apparent serum digoxin concentrations were determined using the Architect® iDigoxin CMIA from Abbott Laboratories in digoxin-free pregnant women (n = 50), and patients with liver disease (n = 50), renal insufficiency (n = 50), kidney (n = 25) or liver (n = 25) transplant, and critical illness (n = 50). Results: In all of the patients included in this study, apparent serum digoxin concentrations were lower than the correspondent quantification limit (< 0.30 μg/L). Conclusions: The Architect® iDigoxin CMIA assay would be relatively free from endogenous DLIS positive interferences. DOI: 10.7754/Clin.Lab.2012.120325

Abstract