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Abstract

Plasma Levels of CXCL1 (GRO-α) and CXCL10 (IP-10) are Elevated in Type 2 Diabetic Patients: Evidence for the Involvement of Inflammation and Angiogenesis / Angiostasis in this Disease State by Seyyed Mohamad Ali Sajadi, Hossein Khoramdelazad, Gholamhossein Hassanshahi, Houshang Rafatpanah, Javad Hosseini, Mehdi Mahmoodi, Mohammad Kazemi Arababadi, Reza Derakhshan, Roshanak Hasheminasabzavareh, Seyed - Mostafa Hosseini - Zijoud, Zahra Ahmadi

Background: Recent evidence has demonstrated that environment and genetic factors play pivotal roles in diabe-tes and its related complications. The significant contributory role of cytokines in pathogenesis of type 2 diabetes is also well documented. This study was aimed to examine and compare both CXCL1 (GRO-α) and CXCL10 (IP-10) circulating levels in type 2 diabetic patients and healthy controls.
Methods: Peripheral blood samples were collected from 100 type 2 diabetic patients and 150 healthy controls. Cir-culating CXCL1 and CXCL10 levels were measured by ELISA.
Results: Elevated serum levels of both CXCL1 and CXCL10 were found in type 2 diabetic patients in comparison to controls.
Conclusions: Elevated levels of CXCL1 and CXCL10 could possibly be used as a marker of inflammation and an-giogenesis/angiostasis in type 2 diabetes.

DOI: 10.7754/Clin.Lab.2012.120225