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ORIGINAL ARTICLEAssociation Between Metabolic Syndrome and the Serum Uric Acid: a Cohort Study by Ping Ren, Mengna Gao

Background: Metabolic syndrome (MS) consists of a cluster of metabolic diseases, and the association between serum uric acid (SUA) and MS has recently been reported in several studies; however, whether SUA is a susceptibility or risk biomarker for the development of MS among Chinese adults is unclear. This study was designed to investigate the relationship between SUA and MS.
Methods: This study involved 4,988 subjects who were followed up for 9 years. Cox regression model was used to analyze the risk factors of MS.
Results: Of the 4,988 subjects, 1,192 subjects developed MS over 9 years of follow-up. The overall 9-year cumulative incidence of MS was 23.9%, ranging from 16.6% in quartile 1 to 35.1% in quartile 4 (p for trend < 0.001). Cox regression analyses indicated that SUA was significantly associated with incident MS (HR comparing quartile 2, 3, and 4 vs. quartile 1, 1.11, 1.33, and 1.78, respectively; p < 0.001) after adjusting for multiple associated parameters. In receiver operating characteristic curve analysis, the cutoff levels for SUA to predict incident MS were 350 μmol/L and 268 μmol/L in males and females, respectively.
Conclusions: The results of this study demonstrated that high SUA concentrations may increase the risk of MS among Chinese adults.

DOI: 10.7754/Clin.Lab.2017.171037