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Abstract |
Chemiluminescence Immunometric Assay for Measuring Osteocalcin in Healthy Children |
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Osteocalcin (OC) was measured in serum samples from 92 children and adolescents (57 females, 35 males) by a two-site chemiluminescence immunometric assay (Nichols Institute Diagnostics, USA), which recognizes the 1 - 19 region of the whole molecule as well as the large N-terminal midregion fragment representing the main part of OC in serum. The highest OC levels are measured between the age of 10 - 15 years. The linear correlations between OC and alkaline phosphatase were 0.65 (p < 0.01) for total alkaline phosphatase (TAP) and 0.61 (p < 0.01) for bone alkaline phosphatase (BAP). |
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