Clinical Laboratory

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Abstract	A Case of Antinuclear Antibody-Negative Dermatomyositis with Interstitial Lung Disease by Ying Qian, Kejie Xie

	Background: Antinuclear antibody (ANA) is important for the diagnosis of autoimmune diseases. When ANA is positive, further specific autoantibody tests are needed to make a definite diagnosis. Methods: This article reports a case of a patient with an autoimmune disease who had inconsistent results in the detection of antinuclear antibodies by indirect immunofluorescence assay (IIFA) and linear immunoblotting assay (LIA). Results: This patient presented with negative ANA and positive anti-SSA/Ro52. Conclusions: IIF-ANA negative and LIA-ANAS positive exists in clinical tests. The combination of IIFA and LIA is important. DOI: 10.7754/Clin.Lab.2024.241037

Abstract