Instructions for the
Preparation of Manuscripts
AIMS AND SCOPE OF Clinical Laboratory (ABBREVIATION: Clin Lab)
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of
laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical
Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and
gene therapies. The journal publishes ORIGINAL ARTICLES, REVIEW ARTICLES, SHORT COMMUNICATIONS, CASE
REPORTS and LETTERS TO THE EDITOR dealing with 1) the scientific background, implementation and
diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'
offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3)
in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning
tissue transplantation and hematopoietic, cellular and gene therapies.
If your manuscript is dealing with one of the above mentioned topics you are always welcome to
submit your manuscript for publication in our journal Clinical Laboratory. Please send the
complete manuscript with tables and figures attended by a cover letter as an e-mail attachment
to the e-mail address: email@example.com.
TYPES OF ARTICLES CONSIDERED FOR PUBLICATION
The majority of articles published in the Journal report original research into laboratory medicine,
transfusion medicine and cell therapy. All articles are subject to review and authors are urged to
be brief; long papers with many tables and figures may require shortening if they are to be accepted
for publication. The text is limited to 7,000 words (not counting summary, tables, figure legends,
and references), with a summary, a maximum of 7 figures and 7 tables and up to 40 references.
Review articles are welcomed by the Journal and are generally solicited by the Editor-in-Chief;
however, authors wishing to submit an unsolicited review article are invited to contact the
Editorial Office prior to submission. Review articles should focus on recent scientific or clinical
advances in an area of broad interest to those in the field of laboratory medicine, transfusion
medicine or cell therapy. Such articles must be concise and critical and should include appropriate
references to the literature. All review articles are rigorously peer-reviewed before a final
publication decision is made.
Review articles should not exceed 7,000 words in length, excluding references and illustrations,
must include a summary of 350 words or fewer, and may not have more than 100 references. The use of
tables and figures to summarize critical points is encouraged; the Journal offers assistance with
preparation or improvement of figures by professional illustrators, once the article is
Short communications definitively documenting either experimental-scientific results or informative
clinical observations in the area of laboratory medicine, transfusion medicine or cell therapy may
be published. Short communications should follow the guidelines for original manuscript and should
not exceed 1,500 words. They should have a maximum of three figures and/or tables, maximum 20
references. A summary of up to 150 words should be followed by continuous text, subdivided if
necessary. Short communications could include important preliminary observations, short methods
papers, therapeutic advances, and any significant scientific or clinical observations which are best
published in this format.
Case reports usually describe either experimental-scientific results or informative clinical
observations of one to three patients or a single family in the area of laboratory medicine,
transfusion medicine or cell therapy. Case reports should include a summary, case presentation,
discussion and conclusion. They may include up to 1,500 words of text, two figures or tables or one
of each, and up to 15 references. A summary of up to 100 words should be followed by continuous
text, subdivided if necessary.
Letters to the Editor
Correspondence which relates to articles which have recently appeared in the Journal or on current
topics in laboratory medicine, transfusion medicine or cell therapy are welcome and will be
published if appropriate and based on priority and interest of readership. A title must be provided
for each letter. Letters should be as short as possible (but no more than 1,000 words of text, 5
10 references and 2 figures or table or one of each). No summary is required.
Editorials usually provide commentary and analysis concerning an article in the issue of the
Journal in which they appear. They may include 1 figure or table. They are nearly always solicited,
although unsolicited editorials may occasionally be considered. Editorials are limited to 900 words,
with up to 10 references.
Book Reviews are generally solicited. We are willing to consider proposals for book reviews,
but please contact the Editorial Office before submitting a review.
Preparation of Manuscripts
Only manuscripts in American English are accepted. Databases used as the basis for analyses must
also be available in English. Manuscripts, including figures, tables and figure
legends, should be submitted as an e-mail attachment attended by a cover letter. The text should be
typed 1½-spaced, on one side of the paper, with a margin of 3 cm. The pages should be numbered
consecutively as well as the lines beginning with the title page. Use a separate sheet of paper for
each of the following sections: title page, summary and key words, text, acknowledgements,
references, individual tables and figure legends, in that order. Preferably use the type Times New
Roman or Courier, and Symbol, as these can be converted into pdf files without problems.
The title page should contain: 1) the title of the article, which should be concise but informative
and should not include abbreviations or brand names. The title is limited to a total of 120
characters and may not exceed 2 lines when written in Times New Roman with font size 16; 2) a
short “running title” of no more than 50
characters (count letters and spaces) typed at the bottom of the title page and identified as such;
3) first name (additional first names must be given as initials with dots) and last name (double
last names must be hyphenated) of each author but not his/her titles, degrees, positions, or
academic ranks; 4) the name(s) of department(s) and institution(s) to which the work should be
attributed; 5) disclaimers, if any; 6) name, address, telephone and FAX numbers, and e-mail address
of the author responsible for correspondence about the manuscript; 7) the source(s) of support in
the form of grants, equipment, or drugs; 8) Declaration of Interest. 1) Please note on the title
of your word document any Declaration of Interest of any of the authors. If there are no conflicts,
please state that fact.
Summary and Keywords
The second page must carry a summary of not more than 350 words. The summary should consist of four
sections labeled BACKGROUND, METHODS, RESULTS, and CONCLUSIONS. These sections should briefly
describe, respectively, the objectives of the study or investigation, the basic procedures (study
subjects and analytic methods), the main findings (giving specific data and the statistical
significance, if possible), and the principal conclusions. Emphasize new and important aspects of
the study. Do not use first-person pronouns in the summary. Keywords should follow the
the same page.
The text of observational and experimental articles is usually divided into sections using the
headings INTRODUCTION, MATERIALS AND METHODS, RESULTS, and DISCUSSION. Long articles may need
subheadings within some sections to clarify content, especially in the Materials and Methods,
Results, and Discussion sections. Other types of articles, such as reviews and editorials, may
require other formats; authors should consult the Editor for guidance. Use as much active voice as
possible in writing.
Introduction. Clearly state the purpose of the article. Summarize the rationale used
for the study or observations. Give only pertinent references: do not review the subject
extensively. Do not include data or conclusions from work being reported.
Case Report. Include only for manuscripts that focus on individual histories.
Materials and Methods. Describe your selection of observational or experimental
subjects (patients or animals, including controls, and the number in each study group) clearly.
Identify the methods, apparatus, equipment, reagents, and procedures used in sufficient detail to
allow other colleagues to reproduce the results. Publication of an original research article implies
that the authors are prepared to distribute freely to academic researchers for their own use any
materials (e.g., cell lines, DNA clones, antibodies) used in the experiments. Provide model name or
number, and the manufacturer’s name (in parentheses) the first time a reagent, an apparatus, or any
equipment is mentioned. Give references to established methods; provide references and brief
descriptions of methods that are not well-known; describe new or substantially modified methods,
give reasons for using them, and describe their limitations.
Statistics. The basis for these guidelines is described in Bailar JC III, Mosteller F.
Guidelines for statistical reporting in articles for medical journals: amplifications and
explanations. Ann Intern Med 1988;108:266-73. Describe statistical methods in detail to enable a
knowledgeable reader with access to the original data to verify the reported results. When possible,
quantify findings and present them with appropriate indicators of measurement error or uncertainty
(such as confidence intervals). Avoid sole reliance on statistical hypothesis testing, such as the
use of p values, which fails to convey important quantitative information. References for study
design and statistical methods should be to standard works (with pages stated) when possible,
rather than to papers in which designs or methods were originally reported. Specify any general-use
computer programs used. Put general descriptions of methods in the Methods section. Define
statistical terms, abbreviations, and most symbols.
Results. Present your results in logical sequence in the text, tables, and/or
illustrations. Do not repeat in the text any data presented in tables and/or illustrations;
emphasize or summarize only important observations, and avoid tables displaying data showing
insignificant differences among groups.
Discussion. Emphasize the new and important aspects of the study and the conclusions
that follow from them. Do not repeat in detail the data given in the Results section or in tables or
illustrations. Include in the Discussion the implications of the findings and their limitations, and
relate the observations to other relevant studies. Link the conclusions with the stated purpose of
the study, but avoid unqualified statements and conclusions not completely supported by the data
presented. Avoid claiming priority and alluding to work that has not been completed.
Recommendations, when appropriate, may be included.
Type each table on a separate sheet. Each table must not be larger than ONE page (vertical or
horizontal) written in Times New Roman and no smaller than font size 10. Larger tables have to be
submitted as "Supplemental Table S1 — Sx" in a seperate file. Tables should be
numbered consecutively with Arabic numerals. A short descriptive heading should be given above each
table and footnotes and/or explanations below. Please prepare your tables in "Word" by the "Table"
function or use xls.-files (Excel). Do not use the tab key for tables.
Please send figures as an e-mail attachment. If possible, use Word or jpg files. Illustrations in
color will be published only if the author pays for the extra cost involved. For more detailed
information on manuscripts see: International Committee of Medical Journal Editors. Uniform
requirements for manuscripts submitted to biomedical journals. Brit Med J 1991;302:338-41.
EACH REFERENCE GIVEN MUST HAVE AT A MINIMUM AN ENGLISH ABSTRACT. REFERENCES TO ARTICLES AVAILABLE
ONLY IN NON-ENGLISH LANGUAGE WILL NOT BE ACCEPTED.
References must be 1½-spaced and numbered consecutively, with Arabic numerals in brackets, as
are cited. References first cited in a table or figure legend should be numbered so that they will
be in sequence with references cited in the text at the point where the table or figure is first
mentioned. List all authors when there are six or fewer; when there are seven or more, list the
first three, followed by “et al.” Please include the PMID (PMID: 8xxxxx4) for each reference. Should
a reference NOT have PMID, please include the link or a link/address where the article can be
obtained in the internet (please make sure that the article is displayed not just the journal
reference - at least an English abstract must be available for reading)
- Jan-Inge Henter, Annacarin Horne, Maurizio Aricó, et al. Diagnostic and therapeutic
guidelines for hemophago¬cytic lymphohistiocytosis. Pediatr Blood Cancer 2007 Feb;48(2):124-31
- Bjerregaard B, Talts JF, Larsson LI. The endogenous envelope protein syncytin is involved in
myoblast fusion. Cell Fusions: Springer; 2011:267-75
Key references only should be given, and exhaustive lists will not be accepted. Few original
communications justify more than 40 references. Reviews may contain more references. Try to avoid
using summaries as references; ‘unpublished observations’ and ‘personal communications’ may not be
used as references, although references to written, not oral, communications may be inserted (in
parentheses) in the text. Give the name of the person from whom the communication was received and
the date (month and year) of the communication. References to manuscripts accepted but not yet
published may be included; designate the journal name, followed by ‘in press’ (in parentheses).
Information from manuscripts submitted but not yet accepted should be cited in the text as
‘unpublished observations’ or ‘submitted for publication’ (in parentheses).
Except for units of measurement, abbreviations are strongly discouraged. The full term for which an
abbreviation stands must precede its first use in the text for ALL abbreviations with the exception
of units of measurement. Use only standard abbreviations. No abbreviations should be used in the
title of the manuscript.
Solutes should be expressed in g/L, mg/L etc. Concentrations of solutes of known molecular weight
may be stated in mol/L or recognized submultiples thereof (mmol/L, μmol/L etc. according to the
international system of units (SI)). Enzyme activities should be reported in U/L. (http://www.bipm.org/en/si/si_brochure/).
Acknowledgments include one or more statements that specify: 1) contributions that should be
acknowledged but do not justify authorship, such as general support by a departmental chairman; 2)
technical help received; 3) financial and material support, specifying the nature of the support;
and/or 4) financial relationships that may pose a conflict of interest. Persons who have contributed
intellectually to the paper, but whose contributions do not justify authorship, may be named and
their function or contribution described as, for example, ‘scientific adviser’, ‘critical review of
study proposal’, ‘data collection’, or ‘participation in clinical trial’. Such persons should have
given written permission to be named. Authors are responsible for obtaining this written permission
from persons acknowledged by name, because readers may infer their endorsement of the data and
conclusions. Technical help should be acknowledged in a paragraph separate from paragraphs
acknowledging other contributions.
All manuscripts are subject to editing for consistency of style by the Editor, the publisher, or
both. Authors will be sent page proofs by the publisher. Proof-reading must be limited to the
correction of typographical errors. Any other changes involve time-consuming and expensive work and
can be charged to the authors. The page proofs should be returned directly to the publisher by email
immediately after receipt to allow for accommodation of authors’ corrections and to avoid
publication delay. If this is not done, the paper will be put on hold without further announcement.
Manuscripts generally will be published in the order that they are accepted.
Reprints can be ordered at quoted prices. The order form, which is sent along with the proofs, must
be completed and returned with the corrected proofs.
Declaration of interest
It is the policy of Clinical Laboratory Publications GmbH to adhere in principle to the Conflict of
policy recommended by the International Committee of Medical Journal Editors (ICMJE, http://www.icmje.org/index.html#conflict).
The authors must declare conflicts of interest (Declaration of Interests). In specific, we request
for the following: 1) all relevant potential conflicts of interest for each named author and/or a
statement of no-conflicts if there are none relevant to the contents of the article for any
author(s), 2) disclosure of how the article is funded, and in specific, the disclosure of any and
all pharmaceutical company funding (partial or total) or a statement that there was no involvement
of a pharmaceutical/other company (if this is the case) and 3) comprehensive explanation of the
role of the sponsors in article preparation (if the article is sponsored in part or whole).
Policy and ethics
The work described in your article must have been carried out in accordance with The Code of
Ethics of the World Medical Association (Declaration of Helsinki) for experiments involving
EC Directive 86/609/EEC for animal experiments http://ec.europa.eu/environment/chemicals/
lab_animals/legislation_en.htm;Uniform Requirements for manuscripts submitted to Biomedical
journals http://www.icmje.org. This must be stated at an
appropriate point in the article.
It is a condition of publication that authors assign copyright or license the publication rights,
including summaries, to Clinical Laboratory Publications GmbH. Authors may, of course, use the
article elsewhere after publication without prior permission from Clinical Laboratory Publications
GmbH, provided that acknowledgment is given to the journal as the original source of publication,
and that Clinical Laboratory Publications GmbH is notified so that our records show that its use is
The Publisher's policy is to use permanent paper from mills that operate a sustainable forestry
policy. Paper has been manufactured from pulp that is processed using acid-free and elementary
chlorine-free practices. Furthermore, the Publisher ensures that the text paper and cover board
used has met acceptable environmental accreditation standards.
The Publisher and the Editors cannot be held responsible for errors or any consequences arising from
the use of information contained in this journal; the views and opinions expressed do not
necessarily reflect those of the Publisher and the Editors; neither does the publication of
advertisements constitute any endorsement by the Publisher and the Editors of the products
A non-refundable handling fee of EUR 250 (plus VAT in European countries) is due prior to
processing, independent of acceptance or rejection.
For further information
64625 Bensheim, Germany