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Abstract

Comparative Evaluation of B-Type Natriuretic Peptide and Mid-Regional Pro-A-Type Natriuretic Peptide Changes from Admission to Discharge in Prognosis of Acute Decompensated Heart Failure Patients by Elisabetta Stenner, Alessandra Buiatti, Giulia Barbati, Marco Merlo, Gianfranco Sinagra, Bruno Biasioli

Background: Mid-regional pro-A-type natriuretic peptide (MRproANP) seems to be non-inferior compared to B-type natriuretic peptide (BNP) for heart failure diagnosis and prognosis; however, no previous studies have investigated the MRproANP in-hospital changes in prognostic role. This study aimed to compare the prognostic accuracy of BNP and MRproANP in-hospital changes in acute decompensated heart failure (ADHF) patients.
Methods: 37 patients with either admission/predischarge BNP and MRproANP data, were investigated. The combined endpoint was cardiovascular death/heart transplantation/readmission for HF.
Results: BNP and MRproANP had a median decrease of 55% [72;45] and 21% [40; 11] respectively in event-free patients; BNP decrease of 34% [48;29] but MRproANP increase of 4% [-7; 25] in patients with cardiovascular events. Prognostic accuracy of deltaBNP and deltaMRproANP was similar.
Conclusions: MRproANP basically trends up in patients with worse outcome and decreases in event-free patients, likely leading to a simpler interpretation although the prognostic accuracy is similar for both peptides.

DOI: Clin. Lab. 2012;58:585-589