You have to be registered and logged in for purchasing articles.


Short-Time Variation in Serum Uric Acid Concentrations in Post-Myocardial Infarction Patients by Jean-Pierre Gonçalves, Milton Severo, Inês Rangel, Carla de Sousa, Maria Júlia Maciel, Carla Lopes

Background: Studies on SUA temporal profile in relation to acute myocardial infarction (AMI) are controversial. The aim of this study was to evaluate the SUA level variations following myocardial infarction.
We studied 222 patients more than 18 years old diagnosed with AMI. SUA was measured at baseline and on day 2 to 4 and day 5 to 8 after AMI. Within and between person variability of SUA following an AMI was estimated using intraclass correlation coefficients (ICC). The change in SUA between each assessment point was analyzed by repeated measures one-way analysis of variance. To evaluated SUA variation post-myocardial infarction and its predictors we used generalized linear mixed-effects models.
Results: The mean plasma concentration of SUA was lower at baseline (58.5 ± 18.9 mg/L). The ICC across the three time points was 0.75 (95% CI 0.70 - 0.80). SUA levels increased 1.33 mg/L per day after AMI (2.3 mg/L/day in women and 1.0 mg/L/day in men). Normouricemic patients had a 1.6 fold increase risk to change to hyperuricemic status per day after AMI (OR = 1.60, 95% CI: 1.27 - 2.00).
Conclusions: Serum uric acid concentration is relatively stable over an eight-day post-myocardial infarction period. However, even a small increase of SUA per day after AMI is associated with a high probability of changing the classification of hyperuricemic status.

DOI: 10.7754/Clin.Lab.2012.120628