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The Changes of Platelet and Platelet Activation Markers in Acute Coronary Syndrome Patients by Lijuan Fang and Jiayong Zheng

Background: To investigate the changes of platelet microparticle (PMPs), monocyte-platelet aggregation (MPAs), and the platelet membrane glycoprotein GPIIb/IIIa ligands (PAC-1) and P-hormone (CD62P) activation ratio changes in acute coronary syndrome (ACS) patients.
Methods: 92 patients were divided into ACS group (54 cases) and coronary angiography negative group (38 cases). 30 cases of age/gender matched healthy control group were recruited. The flow cytometry analysis in each group of PMPs, the MPAs expression of CD62P, GPIIb/IIIa activation ratio, and ROC curve were performed to evaluate the sensitivity and specificity of each parameter.
Results: The healthy control group showed MPAs 5.94 ± 1.93%, PMPs 1.89 ± 0.53%, and PAC-1 2.86 ± 0.93%, the coronary angiography-negative group showed MPAs 11.97 ± 4.92%, PMPs 3.08 ± 1.38%, and PAC-1 3.38 ± 0.92%, and the ACS group showed MPAs 46.27 ± 17.74%, PMPs 5.28 ± 2.44%, and PAC-1 5.34 ± 2.44%. In the ACS group, the area under the ROC curve of each indicator for identifying suspected ACS patients were MPAs (0.952), PMPs (0.807), PAC-1 (0.770), and CD62p (0.656). MPAs showed the highest sensitivity (94.4%) and specificity (84.2%) for the diagnosis of ACS.
Conclusions: acute coronary syndrome, platelet microparticle, monocyte-platelet aggregation, CD62P, GPIIb/ IIIa

DOI: 10.7754/Clin.Lab.2013.121205