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Cystatin C as an Early Marker of Diabetic Nephropathy in Patients with Type 2 Diabetes by You La Jeon, Myeong Hee Kim, Woo-in Lee, So Young Kang

Background: Serum cystatin C has been proposed as an endogenous marker of glomeru-lar filtration rate (GFR) because it shows a correlation with the albumin to creati-nine ratio (ACR) in diabetic nephropathy. The aim of this study was to examine the usefulness of cystatin C as an early marker of diabetic nephropathy.
Methods: From February 2010 to July 2010, 205 outpatients with normo- or microalbuminuria and chronic kidney disease (CKD) of stage III or less were in-cluded in this study. Various renal markers including serum cystatin C and ACR were evaluated.
Results: In the ROC curve analysis, cystatin C showed a performance similar to that of serum creatinine. In addition, cystatin C levels increased with increasing CKD stage I to III and from normo- to microalbuminuria and showed a positive correla-tion with ACR. In a comparison of renal function markers in diabetic patients ac-cording to serum cystatin C level, all markers including ACR, serum creatinine, and eGFR showed significant differences between patients with cystatin C level < 1.06 mg/L and those with cystatin C ¡Ý 1.06 mg/L.
Conclusions: Serum cystatin C is a useful marker of early renal impairment in type 2 diabetic patients because it reflects both a decrease in GFR and elevated ACR.

DOI: 10.7754/Clin.Lab.2013.120804