Background: To investigate the possible association between the polymorphism of es-trogen receptor á (ERá) and Alzheimer’s disease (AD) in Chinese population.
Methods: Cognitive function of patients with AD was evaluated with the Modified Mini-Mental Status Examination (MMSE). ERá polymorphism was detected in 236 AD pa-tients and 236 control individuals. Logistic regression was used in age, body mass index, education, depression, hypertension, diabetes, history of stroke, smoking status, ApoE e4 carrier, and estrogen receptor á genotypes to calculate their odds ratios.
Results: There were no significant differences in PvuII allele and genotype between AD patients and control individuals. The frequencies of XbaI x allele and XbaI xx genotype were significantly higher in AD patients than in control individuals (x2 = 28.116, df = 1, p < 0.0001 and x2 = 16.628, df = 2, p < 0.0001, respectively). The odds ratio for the patients with xx genotype was 2.12 (95%CI = 1.63 - 2.76, p < 0.01).
Conclusions: These findings suggest that ERá XbaI polymorphism is associated with an increased risk of AD in Chinese population. More research is needed to determine the mechanism by which ER á polymorphisms is associated with AD.