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Hsa-mir-182 Downregulates RASA1 and Suppresses Lung Squamous Cell Carcinoma Cell Proliferation by Zhu Yan-jun, Xu Biao, Xia Wei

Background: This work was undertaken to identify the differences in expression of miRNAs, which would predict early-stage non-small cell lung cancer prognosis and recurrence. The results may be helpful to demonstrate one mechanism of lung squamous cancer proliferation.
Methods: Lung squamous cell carcinoma specimens were collected at the time of surgery. Microarray of expression of specific miRNAs in lung squamous cell cancer tissue, were assessed by qRT-PCR.
Results: We found that the hsa-mir-182 family are highly expressed in lung squamous cell carcinoma. Paradoxically, our study reveals mir-182 suppresses cell proliferation in vivo. RASA1 is related to cell apoptosis. We further show that mir-182 downregulates RASA1.
Conclusions: We provide first time evidence through tissue microarray and quantitative PCR validation of mir182 in the expression of lung squamous cell carcinoma. Our data provide a possible mechanism for lung cancer cell proliferation in lung squamous cell cancer and may be helpful in discovering a new strategy to reveal lung squamous cell carcinoma progress.

DOI: 10.7754/Clin.Lab.2013.121131