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Imprecision and Limit of Quantification of the New Architect 25-Hydroxyvitamin D Assay by Marcel J. W. Janssen, Frans A. L. Van Der Horst, Johannes S. Kamphuis

We examined imprecision and limit of quantification (LOQ) of the new Architect 25-hydroxyvitamin D immunoassay in a multicenter setting. Mean intracenter interlot imprecision varied from 22.0 to 5.0%CV in the concentration range of 16 - 92 nmol/L. LOQs were locally determined as 10.8, 11.2, and 13.5 nmol/L. We conclude that the Architect 25(OH)D assay provides a precise and analytically sensitive method for routine measurement of 25(OH)D.

DOI: 10.7754/Clin.Lab.2013.130223