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Determination of the Best Prognostic Value of Serum Tumor Markers in Patients with Suspected Lung Cancer in an Iranian Population by Naseh Sigari, Behzad Mohsenpour, Bahram Nikkhoo, Bayazid Ghaderi, Abdolrahim Afkhamzadeh, Namam-ali Azadi, Fardin Fathi, Mohammad Abdi

Background: Finding a suitable marker with high sensitivity and specificity for early diagnosis of cancer is very desirable. This study was aimed to determine the diagnostic value of serum CYFRA21-1, carcinoembryonic antigen (CEA), and neuron-specific enolase (NSE) for screening of lung cancer patients in western Iran.
Methods: This descriptive analytical case-control study was performed on 30 subjects with malignant and 81 with benign lung cancer. Serum levels of CYFRA21-1, CEA, and NSE were determined.
Results: The concentration of serum tumor markers was significantly higher in the malignant group than in the benign subjects. The highest sensitivity was obtained by measurement of serum NSE (73%). The highest specificity was obtained by measurement of serum CYFRA21-1 (95%).
Conclusions: Our results demonstrate the usefulness of measuring CYFRA21-1 and NSE together for early screening of lung cancer in western Iran.

DOI: 10.7754/Clin.Lab.2013.121003