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Elevated Oxidative Stress Monitored via the Albumin-Thiol Redox State is Correlated with Matrix Metalloproteinase-3 Elevation in Patients with Rheumatoid Arthritis by Kazuha Kizaki, Yusuke Yoshizumi, Teppei Takahashi, Seiichi Era

Background: In rheumatoid arthritis (RA), matrix metalloproteinase-3 (MMP-3) and oxidative stress contribute to joint destruction. However, little is known about the relationship between MMP-3 and oxidative stress in RA.
Methods: We measured the albumin-thiol redox state as a marker of oxidative stress, MMP-3, and the DAS-28 score calculated using CRP values among forty-seven patients (9 males and 38 females) with RA. According to the serum MMP-3 levels, they were divided into two groups (group A: within normal ranges of 36.9 - 121.0 ng/mL for men and 17.3 - 59.7 ng/mL for women; group B: above normal ranges).
Results: The albumin-thiol redox state in group B was significantly oxidized compared with that in group A (p < 0.01). The percentage of oxidized albumin-thiol showed a positive correlation with serum MMP-3 (r = 0.52). DAS-28 and CRP were also correlated with the percentage of oxidized albumin-thiol (r = 0.46, r = 0.44).
Conclusions: The albumin-thiol redox state was significantly oxidized in correlation with serum MMP-3 elevation in RA.

DOI: 10.7754/Clin.Lab.2014.140822