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Association Between Serum Free Fatty Acids Levels and Gestational Diabetes Mellitus: a Cross-Sectional Study by Juanwen Zhang, Jinmei Yao, Ying Zhao, Nengneng Zheng, Yuying Dai

Background: This study aimed to assess the relationship between serum free fatty acid (FFA) levels and gestational diabetes mellitus (GDM) in Chinese pregnant women.
Methods: A cross-sectional study was performed among 779 eligible pregnant women who underwent detailed prenatal visits in Hangzhou, China.
Results: Patients with GDM had significantly higher serum FFA levels than those without GDM. Spearman’s correlation analysis showed that FFA levels were positively correlated with fasting plasma glucose, 1hPG, 2hPG, HOMA-IR, triglyceride, and sialic acid (p < 0.05) and negatively correlated with serum amylase level (all with p < 0.05). Stepwise logistic regression analysis further showed that elevated FFA levels significantly contributed to the risk for GDM.
Conclusions: Our findings suggested that serum FFA levels were significantly associated with GDM.

DOI: 10.7754/Clin.Lab.2016.160312