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Serum Levels and Urinary Excretion of Tenascin-C and TIMP-1 in Acute Kidney Injury by Hanise Ozkan, Yildiz Okuturlar, Hakan Koçoğlu, Mehmet Hursitoglu, Asuman Gedikbasi, İrem K. Utku, Ozgur Okuturlar, Halil Dogan, Sibel O. Serin, Ozlem Harmankaya, Esra Demir, Bulent Demir

Background: Both the extracellular matrix molecule tenascin-C (Tn-C) and tissue inhibitors of metalloproteinases (TIMPs) have a role in tissue injury, inflammation, and remodeling. In this pilot study, we tried to evaluate the role of these markers in acute kidney injury (AKI).
Methods: A total of 52 subjects were enrolled in this study. Group 1 consisted of 27 patients with AKI (stage 1, 2, and 3), and Group 2 consisted of 25 age- and gender-matched healthy subjects. Serum and urine samples (to determine Tn-C and TIMP-1) were obtained from the participants at the beginning of the study. Second samples were obtained from Group 1 patients when renal function improved (at discharge).
Results: Serum TIMP-1 concentrations (admission and discharge) were higher in Group 1 than Group 2 (p = 0.0001 for both comparisons). Tn-C excretion in spot urine was significantly higher in healthy controls than at the admission levels of the patient group (p = 0.036). However, TIMP-1 excretion in spot urine was lower in healthy controls than in admission and discharge levels of the patient group (p = 0.0001 for both comparisons).
Conclusions: Our results show that these biomarkers (especially TIMP-1) may have a role in the pathophysiology of AKI. Further studies are needed in this field.

DOI: 10.7754/Clin.Lab.2019.190233