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Vitamin D in Hypothyroid Patients and Association between Vitamin D and Anti-TPO in Autoimmune Hypothyroidism by Sabira Dabeer, Neha Sharma, Abhay Nagdeote

Background: To find out the incidence of vitamin D deficiency in autoimmune hypothyroidism and the correlation between vitamin D and anti-TPO antibodies.
Methods: This observational study was undertaken in the Biochemistry Department of ESI-PGIMSR & Model Hospital Andheri Mumbai from March 2015 to September 2015. Vitamin D and anti-TPO levels of 101 known cases of hypothyroidism were measured on a Cobas e411. Patients included were between 20 and 50 years old with 63 females and 38 males.
Results: Twenty-two of 101 patients were anti-TPO positive with a mean vitamin D level 10.86 ± 5.91 and mean anti-TPO 59.45 ± 12.46. A negative correlation of r = -0.4949 was found between vitamin D and anti-TPO in patients with anti-TPO positive hypothyroidism.
Conclusions: Low vitamin D levels were found in hypothyroid patients with severe deficiency seen in anti-TPO positive cases.

DOI: 10.7754/Clin.Lab.2020.191235