Abstract
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Prognostic Impact of Preoperative Tumor Markers in Patients with Colorectal Carcinoma
by Basem H. Elesawy, Tariq E. Elmissbah, Mohammed El Sharnouby, Osama Mehanna, Bassem M. Raafat, Khalid E. Hassan, Elsayed A. Elmorsy, Mohamed Imad, Samir A. Badr, Ahmad El Askary
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Background: This study aimed to evaluate the correlation between preoperative CA19-9, CEA, CA125, and AFP levels of and prognosis for patients diagnosed with colorectal carcinoma.
Methods: This was a retrospective study, which involved 400 CRC patients treated with radical resection between January 2022 and December 2024 and categorized into two groups: development (n = 280) and validation (n = 120). Clinicopathological data, including age, gender, operative method, tumor size, tumor location, TNM stage, CA19-9, CEA, CA125, and AFP, was assessed. The patients got checked up every three months for the first year, and then every six months afterwards.
Results: Univariate and multivariate analyses revealed that age (> 70 years), tumor staging, N-stage, preoperative CA125, and CA19-9 were associated with the prognosis of CRC patients. Univariate analysis revealed that tumor size (p = 0.026, HR = 1.64, 95% CI = 0.81 - 3.35) and CEA (p = 0.029, HR = 2.73, 95% CI = 0.24 - 4.42) were associated with the prognosis of CRC patients.
Conclusions: This study revealed the prognostic impact of the tumor markers CA125, CA19-9, and CEA in patients with nonmetastatic CRC.
DOI: 10.7754/Clin.Lab.2025.250231
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