Abstract

Background: Hepatosplenic γδ T-cell lymphoma is a rare subtype of peripheral T-cell lymphomas. It is clinically marked by significant involvement of the liver and spleen, minimal to no lymphadenopathy, and typically follows an aggressive progression. This condition primarily affects adolescents and young adults, with a higher prevalence in males. There are only a limited number of reported cases of this kind of lymphoma associated with hemophagocytic syndrome.
Methods: We report a rare case of a 35-year-old man, who was suffering from Hepatosplenic γδ T-cell lymphoma combined with hemophagocytic syndrome.
Results: The patient was ultimately diagnosed with Hepatosplenic γδ T-cell lymphoma accompanied by hemophagocytic syndrome following a thorough diagnostic evaluation.
Conclusions: In cases where patients exhibit atypical clinical features, the diagnosis of HSTL can solely be established by the relevant morphological, immunohistochemical, molecular, and cytogenetic information.

DOI: 10.7754/Clin.Lab.2025.250357