Abstract
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Diagnostic Value of Coagulation Function Testing for Venous Thrombosis in Patients with Gastric Cancer
by Xing Zhao, Xuan Zhou, Wei-Na Kong, Feng-Ming Tian, Fan Guo, Jie Lv, Xiao Liu, Qi Guo, Guo-Long Hu, Xia Gui, Gang Zhao, Xiu-Min Ma
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Background: This study aimed to explore differences between thromboelastography (TEG) and conventional coagulation tests (CCTs) in evaluating coagulation function and analyze the diagnostic value of each indicator from these two methods in thrombosis among patients with gastric cancer.
Methods: We included 150 patients with gastric cancer and divided them into thrombus and non-thrombus groups. We obtained TEG (R, K, α-angle, and MA) and CCT (PT, APTT, Fib, D-D, and PLT) indicators and analyzed the ROC curve to determine the diagnostic value of each indicator in the occurrence of thrombosis.
Results: Compared with the control group, the gastric cancer group had decreased R and K and increased α-angle and MA. PT, FIB, D-D, and PLT in CCTs increased, while APTT slightly decreased, with statistically significant differences. The ROC results showed that R, K, α-angle, MA, PT, FIB, and D-D are closely related to the occurrence of thrombosis. The area under the curve for combined detection was 0.952 (95% CI: 0.913 - 0.990).
Conclusions: Both TEG and CCTs are of diagnostic value for venous thrombosis in patients with gastric cancer. These two methods should be used together for a better prediction of thrombosis in patients with gastric cancer.
DOI: 10.7754/Clin.Lab.2025.250406
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