Abstract
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Rare Coexistence of Myelodysplastic Neoplasm and CD4 T-cell Lymphoproliferation
by Yuna Choi, Miyoung Kim, Daehyun Chu, Young-Uk Cho, Sang-Hyun Hwang, Eul-Ju Seo, Eun-Ji Choi, Han-Seung Park, Seongsoo Jang
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Background: Myelodysplastic neoplasms (MDS) are characterized by cytopenia and morphologic dysplasia in myeloid cells and are considered a disease of the myeloid lineage. MDS with concurrent lymphoid clonality is rare and mostly occurs in CD8 T-cells.
Methods: We evaluated a 74-year-old man who presented with anemia and lymphocytosis using peripheral blood immunophenotyping, bone marrow examination, and next-generation sequencing.
Results: The patient was diagnosed with MDS with low blasts and an SF3B1 mutation (MDS-SF3B1), concurrent with clonal CD4 T-cell lymphoproliferative disorder, supported by TCR gene rearrangement and distinct mutation profiles.
Conclusions: This is the first reported case of MDS-SF3B1 coexisting with clonal CD4 T-cell proliferation.
DOI: 10.7754/Clin.Lab.2025.250512
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