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Abstract |
Platelet Lipidome Characteristics of Adverse Reactions Associated with Irradiated Aphaeresis Platelets Transfusion in Children |
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Background: In clinical practice, we have observed that compared with red blood cells and plasma, platelet trans-fusion is more likely to cause transfusion adverse reactions, especially in children. Platelets may suffer different degrees of structural and biochemical damage during processing and preservation, and the lipid components contained in platelets may have a significant impact on the generation of transfusion adverse reactions. Therefore, the objective of this study is to identify the key bioactive lipid components that cause adverse blood transfusion reactions especially allergic rash and to explore ways to reduce the adverse transfusion reactions caused by irradiated aphaeresis platelets.
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