Abstract
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Associations of CRP, PCT, NC, and NLR with Anti-Infective Effect on Patients with Hematological Malignancy and Pulmonary Infection
by Yuxuan Su, Xiaoting An, Xiaoxia Zhang, Liang Li, Jinman Zuo, Shuya Ge, Jianjun Bian
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Background: We aimed to analyze the associations of C-reactive protein (CRP), procalcitonin (PCT), neutrophil count (NC), and neutrophil-to-lymphocyte ratio (NLR) with the anti-infective effect on hematological malignancy patients complicated with pulmonary infection during chemotherapy.
Methods: One hundred hematological malignancy patients complicated with pulmonary infection during chemotherapy admitted from March 2020 through December 2024 were selected as a study group, while another 100 patients without pulmonary infection in the same period were selected as a control group. Their serum CRP and PCT levels, NC, and NLR were compared. The study group was further divided into an effective group and an ineffective group, and the two groups were compared in regards of serum CRP and PCT levels, NC, and NLR.
Results: The serum CRP and PCT levels, NC, and NLR in the study group were higher than those in the control group (p < 0.05). The serum CRP and PCT levels, NC, and NLR in the ineffective group were higher than those in the effective group (p < 0.05). Serum CRP, PCT, NC, and NLR were risk factors for ineffective anti-infective therapy (odds ratio > 1, p < 0.05). The areas under the ROC curves of serum CRP, PCT, NC, and NLR alone and in combination for predicting the anti-infective effect were 0.748, 0.818, 0.840, 0.770, and 0.952, respectively.
Conclusions: CRP, PCT, NC, and NLR are high in hematological malignancy patients complicated with pulmonary infection during chemotherapy. Their levels are related to the outcome of anti-infective therapy, and the combination of the four can effectively enhance the predictive value.
DOI: 10.7754/Clin.Lab.2025.250431
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