Abstract

Background: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a significant pathogen linked to severe infections like pneumonia, which can lead to complications such as thrombotic microangiop-athy (TMA), characterized by microthrombi causing ischemia and organ dysfunction. Diagnosing these complications remains challenging, requiring timely identification and intervention.
Methods: This case report presents a 24-year-old male with CA-MRSA pneumonia complicated by intracranial diffuse TMA, manifesting as high fever, wheezing, respiratory failure, and altered consciousness. Comprehensive laboratory and imaging studies confirmed the diagnosis. The patient recovered completely with antibiotic therapy, mechanical ventilation, and anticoagulation.
Conclusions: This case highlights the severity of CA-MRSA pneumonia and its potential for intracranial microvascular complications, emphasizing the importance of brain MRI in septic patients with neurological impairment and the need for early intervention. To our knowledge, this represents the first reported case of CA-MRSA pneumonia-associated intracranial diffuse TMA, providing novel clinical insights for managing similar presentations.

DOI: 10.7754/Clin.Lab.2025.250663