|
|
Background: Acute pancreatitis (AP) is an acute inflammatory disease primarily involving the pancreas and can affect all age groups. Acute recurrent pancreatitis (ARP) refers to two distinct episodes of AP. In children, pancreatitis typically presents as a single uncomplicated episode, but it can also manifest as ARP and progress to chronic pancreatitis. Pediatric AP differs clinically from adult AP and requires specific diagnostic and therapeutic approaches. Although pediatric AP has lower mortality rates compared to adult AP, it may still lead to significant morbidity and complications. This study aimed to evaluate the relationship of laboratory parameters and inflammatory scores with etiology, clinical features, and prognosis in pediatric pancreatitis.
Methods: The Akgün database of Malatya Training and Research Hospital was retrospectively reviewed. Between January 2020 and December 2024, epicrisis reports of 46 hospitalized patients coded as ICD-10 K85 (acute pancreatitis) or K85.9 (unspecified acute pancreatitis) were examined. Patients were classified according to the INSPPIRE (International Study Group of Pediatric Pancreatitis: In Search for a Cure) criteria as acute pancreatitis (AP) or acute recurrent pancreatitis (ARP). Nine patients who did not meet inclusion criteria were ex-cluded, and the study was conducted with the remaining 37 cases.
Results: Among the patients, 10 (27%) were diagnosed with ARP, while 27 (73%) presented with AP. The most common etiologies were idiopathic (n = 20, 54.1%), cholelithiasis (n = 10, 27%), and drug-induced pancreatitis (n = 7, 18.9%). Among drug-related cases, valproic acid was identified in 42.8% (3 patients), metronidazole in 28.6% (2 patients), and NSAIDs in 28.6% (2 patients). Laparoscopic cholecystectomy was performed in 5.4% (2 patients). All patients were monitored in the ward and discharged with full recovery.
Conclusions: In our study, the increase in creatinine levels was associated with a higher risk of ARP, highlighting the importance of renal function markers in pancreatitis. Furthermore, the positive correlation between amylase, lipase, and the SIRI index with the length of hospital stay suggests that these parameters may be useful in predicting disease severity.
DOI: 10.7754/Clin.Lab.2025.250914
|
